<body>
<p><strong>FeyeCon<br />
</strong><em>creating the future</em></p>
<p><strong>- textiles & polymers<br />
- food cosmetics<br />- pharmaceuticals & nutraceuticals<br />
- equipment</strong></p>
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<p><strong>Introduction</strong></p>
<p>FeyeCon Development & Implementation develops and manufactures products with supercritical CO<span class="sub"><span>2</span></span> technology. Using the possibilities that are offered by the processes with supercritical CO<span class="sub"><span>2</span></span> many new and superior products become possible. Applications are found in food, pharma, textile and other industrial fields. Creativity and flexibility are our core values. Combined with hard work to achieve our goals we are able to achieve over 90% of the challenges we meet. Cutting edge technology is maintained at a high level through cooperation with leading university groups. Pilot plant facilities are available for small scale production. A clean room facility is available for pharmaceutical applications. For full scale production our staff is most happy to design, engineer and build large scale facilities for your products. Contact us to discuss your business case with our specialists or business people.</p>
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<p><strong>Supercritical fluids</strong></p>
<p><em>Versatile Applications<br />
</em>The wide potential range of application makes processes with CO<span class="sub"><span>2</span></span> an attractive method for the production of high quality products. Compressed gases like CO<span class="sub"><span>2</span></span> can be an alternative solvent to conventional organic solvents. Also it can provide an entirely new route to a new product. The products are available for cosmetic, pharmaceutical, nutraceutical, food purposes, and for the polymer, wood, and textile industry. CO<span class="sub"><span>2</span></span> is inexpensive and recyclable, and thus also attractive for bulk production. In most cases the process cost are lower. We will work out cost efficient solutions and demonstrate that high pressure equipment is not exceptionally expensive.</p>
<p><em>Tunable<br />
</em>At atmospheric conditions CO<span class="sub"><span>2</span></span> is a gas. By increasing temperature and pressure above 31ºC and 73 bar respectively CO<span class="sub"><span>2</span></span> is present as one phase neither liquid nor gaseous but “supercritical” (a unique combination of gas-like viscosity liquid-like density). The density can be tuned by variation of pressure and/or temperature which changes the solvent power of the CO<span class="sub"><span>2</span></span>. A rapid reduction of the pressure decreases the solubility and is beneficial for the micronisation of solids. The low surface tension of a supercritical fluid and its high diffusivity allow penetration even into the smallest pores. This makes it especially suitable for extraction, rinsing, dyeing, and impregnation.</p>
<p><em>Non-toxic<br />
</em>Carbon dioxide (CO<span class="sub"><span>2</span></span>) is used most widely for supercritical fluid processes because of its relatively low critical temperature and pressure. The use of supercritical CO<span class="sub"><span>2</span></span> is particularly attractive because it is an environmentally benign solvent and can be recycled easily. It is non-flammable and relatively non-toxic.</p>
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<p><strong>Product applications</strong></p>
<p><em>FeyeCon uses CO<span class="sub"><span>2</span></span> technology in many fields aiming at new products or aiming at the improvement of existing products regarding cost reduction or waste minimisation. Feel free to scan our product applications and get inspired by the possibilities of your business.</em></p>
<p><strong>Drug delivery</strong> - Supercritical fluid technology opens windows in the delivery of low soluble compounds.</p>
<p><em>Is your compound available?</em><br />
Up to 40% of all new pharmaceutical compounds have a poor biological availability due to their low solubility. This property sets serious challenges for the formulation departments of the pharmaceutical companies worldwide. For the formulation of poorly soluble compounds there are different strategies using a combination of supercritical fluid (SCF) technology. The high densities and the fast diffusivity in SCFs opens windows in the precipitation processes, leading to preferred particle morphology and co-precipitation possibilities.</p>
<p><strong>Pulmonary protein delivery</strong> - Get rid of the needle! Enhance pulmonary uptake by using tailor-made particles.</p>
<p><em>Get rid of the needle!</em><br />Pulmonary protein delivery has tremendous benefits as well as drawbacks. Typical benefits are the low enzymatic activity and large surface area. Large molecules, however, can have low bio-availability using this administration route. Particle engineering and uptake enhancers are used to enhance pulmonary uptake of macromolecules. Particles for pulmonary delivery made by supercritical fluids technology can be tailored to exhibit correct physical and aerodynamic behaviour.</p>
<p><strong>Medical cannabis</strong> - Reliable administration of cannabis derivatives for therapeutical and analytical applications.</p>
<p><em>Reliable, efficient, pure and predictable.</em><br />Cannabis is progressively accepted as a powerful painkiller. Unfortunately, its use is often associated with undesired psycho-active side effects. Hence, better quality cannabis and derivatives are required, as well as improved routes for administration. FeyeCon has applied its broad experience on sub- and supercritical gas technology on the development of improved cannabis-products. FeyeCon is capable of isolating individual cannabinoids to >99.7% by preparative liquid chromatography. Resulting products can be used as analytical standards or as highly specific sedatives.</p>
<p><strong>Micronisation</strong> - New micronisation technology opens possibilities for product development and manufacturing.</p>
<p><em>Ultra-fine soft materials.<br />
</em>Micron-size powders of fat, wax or other ductile materials offer opportunities for new products and inventive processing. A New melt micronisation technology produces particles of various structures with fine details down to about 100 nm. Such powders carry uncharted potential for development of products and production technologies. In this new field, success with consumer products depends on innovations in product formulation, processing and equipment development. Our expertise and experience with melt-micronisation helps you tailor your application.</p>
<p><strong>Dispersion</strong> - Dispersion of powders in a liquid carrier using CO2 requires less energy and results in better quality.</p>
<p><em>Abrasion free dispersion at gentle temperatures.</em><br />
With standard dispersion processes, energy is introduced to the agglomerates by impact and shear, like when using a bead mill. Most of the energy is dissipated as heat. With this new technology compressed CO<span class="sub"><span>2</span></span> is dissolved in the dispersion. Using a rapid depressurisation the CO<span class="sub"><span>2</span></span> will expand and disperse the particles. The energy acts from the inside on the agglomerates to disperse them. No heat is generated by the expansion.</p>
<p><strong>Mild fractionation</strong> - High pressure fractionation offers a save way to recover sensitive compounds from liquid mixtures.</p>
<p><em>Discover and recover the best.</em><br />
Active compounds for food-supplements or cosmetic applications can be efficiently recovered from liquid mixtures using high pressure fractionation employing supercritical CO<span class="sub"><span>2</span></span> and a packed column. The advantage over conventional distillation is that degradation of sensitive compounds is avoided. This offers various opportunities for the separation of valuable, but sensitive compounds that are used as ingredients in e.g. nutraceutical, pharmaceutical, or cosmetic products.</p>
<p><strong>FeyDry</strong> - The FeyDry process enables fast drying without exposing your product to extreme temperatures.</p>
<p><em>Gentle drying for temperature-sensitive components.</em><br />
Drying with conventional techniques (hot air drying, freeze drying) often leads to damage to the product. The FeyDry process enables products to be efficiently dried at temperatures close to ambient. It uses carbon dioxide as a water carrier and a zeolite as drying medium. This allows the process to be faster than the conventional drying process. Application of the process is particularly interesting for temperature sensitive materials such as vegetables, pharmaceuticals, and nutraceuticals.</p>
<p><strong>CO<span class="sub"><span>2</span></span> spray drying</strong> - An alternative drying process for aqueous solutions of thermolabile and solvent-sensitive compounds.</p>
<p><em>The fast and safer alternative.</em><br />
FeyeCon has developed a process for the drying of aqueous solutions of proteins, sugars, and other water soluble compounds. The process is specifically suitable for drying of thermolabile and solvent-sensitive compounds. It is a faster and benign alternative to conventional spray drying and freeze drying. The process is suitable for large scale operation and processing costs are equal to or lower than for freeze drying. Gentle temperatures of 35-40°C result in minimum degradation of the active compounds.</p>
<p><strong>Textile dyeing</strong> - Cost effective, water free and environmentally friendly process for dyeing textile fabrics.</p>
<p><em>Water free and environment friendly.</em><br />FeyeCon has developed a process and a machine for dyeing of textile material in supercritical carbon dioxide. It is a complete water free dyeing process with considerable lower operational costs than conventional dyeing processes. A beam dyeing machine for dyeing synthetic fabric with disperse dyes has been developed. Natural fibres can be dyed as well, using specially designed reactive dyes. The machine is easily implemented in current textile dyeing plants. (In co-operation with <a href="http://www.storkprints.com/" target="_blank">Stork Prints bv</a>).</p>
<p><strong>Dry-cleaning of textiles</strong> - Non-toxic, cost-effective and odourless process for cleaning delicate clothing, using liquid CO2.</p>
<p><em>A better process for cleaning delicate clothing.</em><br />
Dry-cleaning is a process for removing soils and stains from fabrics and garments which uses a non-aqueous solvent. The use of water as a cleaning solvent for fabrics causes wrinkles, shrinkage and loss of shape. Dry-cleaning solvents have no effect on the structure of the fabric. However, the commonly used dry-cleaning solvents are toxic and environmentally harmful. Liquid carbon dioxide (CO<span class="sub"><span>2</span></span>) is an ideal solvent to replace them.</p>
<p><strong>Polymer foaming</strong> - Cheaper, environmentally friendly, versatile and with adjustable properties: polymer foaming using CO2.</p>
<p><em>A sound method to expand your business.</em><br />
Polymer foams are used in construction, packaging, footwear, the automotive industry etc. Carbon dioxide (CO<span class="sub"><span>2</span></span>) is very soluble in many polymers and can be efficiently used to foam polymers. The versatile process can either be carried out batch-wise or in a continuous process. In comparison with other foaming processes, CO<span class="sub"><span>2</span></span> is environmentally sound, fast, and cheap.</p>
<p><strong>High-pressure systems</strong> - Custom engineered systems and components for supercritical separation and particle technology.</p>
<p><em>CO<span class="sub"><span>2</span></span> supply unit </em>FeyeCon builds custom fit CO<span class="sub"><span>2</span></span> supply systems that will suit your demand. From simple configurations to complex installations. <em>CO<span class="sub"><span>2</span></span> pump </em>FeyeCon has developed a high pressure circulation pump with increased capacity compared to magnetic coupling pumps and at reduced cost compared to dynamic axis sealing systems. <em>Sapphire cells </em>Some high pressure processes require visual inspection. FeyeCon has designed sapphire cell equipment for the measurement of fluid phase equilibria and observation of processes in high pressure systems. <em>Clean room facility </em>FeyeCon has a clean room for supercritical processes for the production of your test batches on a food grade or pharmaceutical level.</p>
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<p><strong>Ready-made products</strong></p>
<p><em>The R&D activities of FeyeCon have lead to products that are available directly without further development. Contact our business people about prices, delivery times, and about special product specification you require.</em></p>
<p><em>Cannabis extracts and cannabinoids as API or analytical standard<br />
</em><font face="Verdana, Helvetica, Arial">Extracts and API's can be produced on demand according to Dutch and European regulations on controlled substances. (In co-operation with <font color="#0000FF"><u><a href="http://www.bactimm-bv.com/Farmalyse/" target="_blank">Farmalyse bv</a></u></font>). </font>FeyeCon produces medicinal cannabis extracts in different purities. The available grades vary from a crude extract with a 60% THC content to a cGMP produced API of 99+ %. Extraction takes place in our Class C Cleanroom facility. Further purification is carried out in co-operation with our business partner<font face="Verdana, Helvetica, Arial"> <a href="http://www.bactimm-bv.com/Farmalyse">Farmalyse bv</a>.</font> We deliver cannabinoid products only to companies with the required licences for controlled substances.</p>
<p><font face="Verdana, Helvetica, Arial"><em>High pressure CO2 circulation pump</em><br />
</font>Current ‘small’ model specifications: Flow: 30-40 m<sup>3</sup>/h, head: 70m = 3.5 bar for CO<span class="sub"><span>2</span></span> at a density of 500 kg/m<sup>3</sup>, 3000 rpm, motor: 7.5 kW, working conditions: up to any pressure and 120°C (for instance 350 bar and 120°C). There is an increasing demand for centrifugal pumps that operate at a high pressure (HP). FeyeCon has developed a HP circulation pump with increased capacity compared to magnetic coupling pumps and at reduced cost compared to dynamic axis sealing systems. Based on one of two prototypes, a circulation pump was implemented into a semi-full scale dyeing machine. Ask us for the results.</p>
<p><em>High-pressure viewcell<br />
</em>Available as multi purpose design, suitable for solubility measurements, phase equilibrium data and visualisation of dyeing crystallisation or precipitation processes. Working conditions: up to 350 bar and 150°C. Some HP processes require visual inspection. Transparent sapphire has unique physical properties for this purpose. FeyeCon has designed Sapphire cell equipment for the measurement of fluid phase equilibria and observation of processes in HP systems. The set-up is installed in an oven, and allows fast and easy opening and cleaning of the cells.</p>
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<p><strong>Company profile</strong></p>
<p><em>FeyeCon Development & Implementation B.V., founded in 1992, is a privately owned company starting as a spin-off company from Delft University of Technology. Within the last 14 years it has developed into a corporation with 17 employees and own facilities. Our employees are industrial experienced and have academic degrees (physics, biochemistry, chemical engineering, chemistry, pharmacy, mechanical engineering).</em></p>
<p>FeyeCon operates in the development phase of products, where creative but simple solutions make all the difference. We use our knowledge of CO<span class="sub"><span>2</span></span> technology to help our customers with the development of new, improved, or more cost effective products. We serve customers in the food, pharmaceutical and process industry.</p>
<p><em>Experiment and production<br />
</em>We operate from a scientific level to an industrial level for products and processes. An experimental set up is often constructed and commissioned within days and experimental results are delivered within weeks with the proof of principle and semi-scale production. Generally our projects proceed in these phases:<br />
- Proof of principle and economic feasibility<br />
- Research and development<br />
- Implementation and product qualification</p>
<p><em>Implementation<br />
</em>High-pressure technology is generally believed to be an expensive alternative. In particular our specific knowledge of the suitable equipment for such systems can in fact make high-pressure technology economically the more favourable alternative. Our experience with the application of certain new technologies is reflected by our work as consultant. However, we are not afraid to face the consequences and carry the implementation trajectory. Because the environment friendly and innovative nature of our technology, research and development activities executed in cooperation with other companies are often subsidised with European or national grants.</p>
<p><em>Business activities<br />
</em>Projects are defined for both national and international customers from industry, institutes, and universities. We take customer requirements and turn them into clear deliverables (products) and milestones in our quotations. We spend 40% of our time on contracts. Co-operations and joint ventures consume 50% and 10% is of our time is used for our own projects. We are willing to share the risks and rewards with our clients.</p>
<p><em>Alliances<br />
</em>FeyeCon works on joint projects with several strategic partners. With the <a href="http://www.3me.tudelft.nl/live/pagina.jsp?id=ef27cd6c-fa3f-4940-9111-cce963ea8b3c&lang=en">Delft University of Technology</a> we have several co-operations in particular for non commercial research projects. For the isolation and fractionation of natural compounds we are able to offer various analyses and toxicity tests in co-operation with <a href="http://www.prisna.nl/">Prisna bv</a>. Together with <a href="http://www.storkprints.com/">Stork prints</a> we developed a low cost alternative high-pressure vessel that, among others, can be used for textile dyeing.</p>
<p><em>Confidentiality<br />
</em>For most of our partners and clients the fact and nature of the work is confidential. Of course we treat all our projects as such. Secrecy agreements and exclusivity contracts can complete the co-operation.</p>
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<p><strong>Patents & publications</strong></p>
<p><strong><span class="darkgrey">Patents</span></strong></p>
<ul>
<li><span class="klein"><b>“Dehydration method- method of dehydrating pieces of intact plant or animal tissue”,</b> WO 2005122776 A1.</span></li>
<li><span class="klein"><b>“Method for particle precipitation using near-critical and supercritical antisolvents”</b>, WO 2004006893 A1.</span></li>
<li><span class="klein">“<b>Device and method for the piece-wise or batch-wise refining of pieces of a substrate, in particular a textile substrate, under high pressure</b>”, WO2004009897, AU2003253505, NL1021142C.</span></li>
<li><span class="klein">“<b>Inrichting voor het stuksgewijs of partij-gewijs onder hoge druk behandelen van stukken van een substraat</b>”, NL application, subm. nov. 2004.</span></li>
<li><span class="klein">“<b>A method of dyeing a substrate with a reactive dyestuff in supercritical or near supercritical carbon dioxide</b>”; EP Application no. 04078035.5, 04078036.3, 04078038.9, subm. nov. 2004.</span></li>
<li><span class="klein"><b>“Process for small particle formation by controlled nucleation and precipitation”, </b>WO 2003086606 A1, EP 1494796</span></li>
<li><span class="klein">“<b>Dry cleaning articles using densified carbon dioxide for the removal of stains from articles of clothing</b>”, WO 03/062520.</span></li>
<li><span class="klein">“<b>A Method of Processing Lipid Materials in gases</b>”, WO 02/102947, EP 1468135.</span></li>
<li><span class="klein">“<b>Dyeing textile materials with reactive disperse dyes in supercritical fluids with good dye fixation by dyeing textile materials with supercritical fluids having relative humidity 10-100%</b>”, EP1126072, US6620211, US2001020311, JP2001316988, NL1014395C.</span></li>
<li><span class="klein">“<b>Dissolving device and method for dissolving a particulate solid in a supercritical or almost critical fluid, and dyeing device</b>”, EP1152081, 07.11.2001, also published as: US6598252, US2001051124, JP2002018249, NL1015085C. </span></li>
<li><span class="klein">“<b>Structured packing for mass transfer and/or heat exchange between a liquid and a gas</b>”, WO 98/50752.</span></li>
<li><span class="klein">“<b>Process and Device for Separating a Mixture or Extracting a Material</b>”, WO 94/13377.</span></li>
</ul>
<p></p>
<p><strong><span class="darkgrey">Thesis</span></strong></p>
<ul>
<li><span class="klein">Process and Equipment Development for Textile Dyeing in Supercritical Carbon Dioxide, M. van der Kraan, Delft University of Technology, 2005, ISBN 90-90199128.</span></li>
<li><span class="klein">Cotton Dyeing in Supercritical Carbon Dioxide, M.V. Fernandez Cid, Dissertation Delft University of Technology, 2005, ISBN-10: 9090197656, ISBN-13: 9789090197654 ]</span></li>
<li><span class="klein">Dry-cleaning with high-pressure carbon dioxide, M.J.E Van Roosmalen, Dissertation Delft University of Technology 2003, ISBN 90-9017391-9</span></li>
<li><span class="klein">Supercritical fluid extraction of metals from contaminated solid matrices, C. Kersch, Dissertation Delft University of Technology, 2003, ISBN: 90-9017604-7</span></li>
<li><span class="klein">Late-transition metal catalyzed polymerizations of olefins in supercritical carbon dioxide, T.J.de Vries, 2003, Eindhoven University of Technology</span></li>
<li><span class="klein">Isoeletric Precipitation of Proteins using CO<sub>2</sub>, G.W. Hofland, Dissertation Delft University of Technology, 2001</span></li>
<li><span class="klein">Supercritical Crystallisation: Volatile Components as Anti-Solvents, F.E. Wubbolts, Dissertation Delft University, 2000</span></li>
<li><span class="klein">High-Pressure-High-Temperature Fluid Phase Behaviour of the systems CF<sub>4</sub>+H<sub>2</sub>O, CF<sub>4</sub>+H<sub>2</sub>O+NaCl, CHF<sub>3</sub>+H<sub>2</sub>O, CHF<sub>3</sub>+H<sub>2</sub>O+NaCl, P.J. Smits, Dissertation Delft University of Technology, 1998</span></li>
<li><span class="klein">Active Transport through Liquid Membranes Mimicking Biological Membranes in the Case of some Biological Active Compounds”, D. Trambitas, Romanian Academy, Institute of Physical Chemistry, Bucharest, 1997</span></li>
<li><span class="klein">Hydrodynamics and Mass Transfer in Packed Columns and their Applications for Supercritical Separations, G.F. Woerlee, Dissertation Delft University of Technology, 1997</span></li>
</ul>
<p></p>
<p><strong><span class="darkgrey">Publications</span></strong></p>
<ul>
<li><span class="klein">Opening new operating windows for polymer and protein micronisation using the PCA process, J. Supercrit. Fluids, 36, 216-224, 2006.</span></li>
<li><span class="klein">Acid-catalysed methanolysis reaction of non-polar triazinyl reactive dyes in supercritical carbon dioxide, J. Supercrit. Fluids, 2005 (accepted).</span></li>
<li><span class="klein">A significant approach to dye cotton in supercritical carbon dioxide with fluorotriazine reactive dyes, J. Supercrit. Fluids, 2005 (in review).</span></li>
<li><span class="klein">Dyeing of natural and synthetic textiles in supercritical carbon dioxide with reactive disperse dyes, J. Supercrit. Fluids, 2005 (submitted).</span></li>
<li><span class="klein">Equilibrium study on the disperse dyeing of polyester textile in supercritical carbon dioxide, Textile Research Journal, 2005 (submitted).</span></li>
<li><span class="klein">Operating regimes and mechanism of particle formation during the precipitation of polymers using the PCA process, J. Supercrit. Fluids, 35, 147-156, 2005</span></li>
<li><span class="klein">The influence of variable physical properties and buoyancy on heat exchanger design for near- and supercritical conditions, J. Supercrit. Fluids, 34, 99, 2005.</span></li>
<li><span class="klein">Excellent dye fixation on cotton dyed in supercritical carbon dioxide using fluorotriazine reactive dyes, Green Chemistry, 7, 609, 2005.</span></li>
<li><span class="klein">Novel Process to Enhance the Dyeability of Cotton in Supercritical Carbon Dioxide,Textile Research Journal, 2005(in review).</span></li>
<li><span class="klein">Catalytic polymerization of olefins in supercritical carbon dioxide, In: Supercritical carbon dioxide in polymer reaction engineering; Editors: M.F. Kemmere, Th. Meyer, 157-187, Wiley-VCH, Book Chapter, 2005</span></li>
<li><span class="klein">Supercritical fluid extraction: A study on metal recovery and regeneration of beta- diketones and organophosphorus extractants, Solvent Extr. & Ion Exch., 23, 189-212, 2005</span></li>
<li><span class="klein">Design and performance of a technical-scale machine for polyester dyeing in scCO2, In: 10th European meeting on supercritical fluids, 12-14 dec. 2005, ISASF conference proceedings, Colmar-France</span></li>
<li><span class="klein">Maximum attainable coloration of polyester in supercritical carbon dioxide, In: Proceedings of The 7<sup>th</sup> Italian Conference on Supercritical Fluids and Their Applications, 13-16 June 2004, Trieste, Italy</span></li>
<li><span class="klein">Amino acid based surfactants for dry-cleaning with high-pressure carbon dioxide, J. Supercrit. Fluids, 32, 243-254, 2004.</span></li>
<li><span class="klein">Kinetics Study of a dichlorotriazine reactive dye in supercritical carbon dioxide, J. Supercrit. Fluids, 32, 147, 2004.</span></li>
<li><span class="klein">Characterization of polyethylenes produced in supercritical carbon dioxide by a late-transition-metal catalyst, Macromolecules, 37(11), 4241-4246, 2004.</span></li>
<li><span class="klein">Leachability of metals from fly ash: leaching tests before and after extraction with supercritical CO2 and extractants, Hydrometallurgy, 72, 119-127, 2004.</span></li>
<li><span class="klein">Anhydrous supercritical carbon dioxide method for the controlled silanization of inorganic nanoparticles, Advanced Materials (Weinheim, Germany), 16(8), 739-744, 2004.</span></li>
<li><span class="klein">Textile dyeing in supercritical carbon dioxide, In: Proceedings of the 6th International Symposium on Supercritical Fluids, 28-30 April 2003, Versailles, France.</span></li>
<li><span class="klein">Surfactants for particle removal in dry-cleaning with high-pressure carbon dioxide, In: Proceedings of the 6<sup>th</sup> International Symposium on Supercritical Fluids, Versailles, France, 2003.</span></li>
<li><span class="klein">Sapphire cells for high pressure observations, In: Proceedings of the 6<sup> th</sup> International Symposium on Supercritical Fluids, Versailles, France, 2003.</span></li>
<li><span class="klein">Heat transfer in high-pressure carbon dioxide, In: Proceedings of the 6<sup> th</sup> International Symposium on Supercritical Fluids, Versailles, France, 2003.</span></li>
<li><span class="klein">Dry-cleaning with high-pressure carbon dioxide, In: Proceedings of the 41st wfk International Detergency Conference, Düsseldorf, Germany, 2003, p. 236.</span></li>
<li><span class="klein">Ligand assisted extraction of metals from fly ash with supercritical CO<sub>2</sub>, In: ACS Symposium Series, Vol.860, 2003; pp.80-102.</span></li>
<li><span class="klein">Antisolvent effect of carbon dioxide in ethylene-PEP systems, SAFT and Sanchez-Lacombe modeling, Recent Res. Dev. Appl. Polym. Sci., 1, 171-188, 2002.</span></li>
<li><span class="klein">Application of supercritical carbon dioxide in polymer processes, Recent Res. Dev. Appl. Polym. Sci., 1, 37-53, 2002.</span></li>
<li><span class="klein">A comprehensive model for the pressure drop in vertical pipes and packed columns. Chemical Engineering Journal, 84(3), 367-379, 2001.</span></li>
<li><span class="klein">A capacity model for vertical pipes and packed columns based on entrainment, Chemical Engineering Journal, 84(3), 355-366, 2001.</span></li>
<li><span class="klein">Expression for the Viscosity and Diffusivity Product Applicable for Supercritical Fluids, Ind. Eng. Chem. Res., 40(1), 465-469, 2001.</span></li>
<li><span class="klein">Phase Behavior of Poly(ethylene-co-propylene) in Ethylene and Carbon Dioxide: Experimental Results and Modeling with the Statistical Associating Fluid Theory Equation of State, Ind.Eng.Chem.Res., 39, 4510-4515, 2000.</span></li>
<li><span class="klein">Isoelectric precipitation of soybean protein using carbon dioxide as a volatile acid, J. Chromatogr. B, 743, 357-368, 2000.</span></li>
<li><span class="klein">Isoelectric precipitation of casein using high-pressure carbon dioxide, Ind. Eng. Chem. Res., 38, 4919-4927, 1999.</span></li>
</ul>
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<p><strong>Contact information</strong></p>
<p><strong>FeyeCon D&I B.V.</strong></p>
<p><em>Main address<br />
</em>Rijnkade 17a<br />
1382 GS Weesp<br />
The Netherlands<br />
Phone +31 294 45 77 33<br />
Fax +31 294 45 88 66<br />
E-mail <a href="mailto:office@feyecon.com">info@feyecon.com</a></p>
<p><em>Office in Delft:<br />
</em>Leeghwaterstraat 44<br />
2628CA Delft<br />
Phone +31 15 278 -5498/-3839</p>
<p></p>
<p><strong>GMP</strong><em> (Good Manufacturing Practice)</em></p>
<p><em>Cleanroom facility<br />
</em>In our main laboratories at FeyeCon a cleanroom facility is available for the cGMP production of clinical lots. For the moment various extraction processes can be carried out. After extension of the equipment (from mid 2006) we are also can offer a variety of particle engineering techniques such as SAS (supercritical antisolvent), rapid expansion of a supercritical solution (RESS), and supercritical spray drying.</p>
<p><em>Production capacity<br />
</em>The vessels (5 and 7 litre) allow a production of up to 2 kilo per batch. For particle engineering a larger particle collection vessel is designed to enable a daily production of 10 kg.</p>
<p><em>GMP<br />
</em>The cleanroom is of class C, and it is equipped with a class D gowning room. Currently, the validation of processes and equipment is in process. We aim to comply to cGMP annex 13 for the production of clinical materials by July 2006.</p>
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<p><strong>Disclaimer</strong></p>
<p><em>Liability</em> For documents and software available from this domain, FeyeCon does not warrant or assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed. <em>External Links</em> Some pages may provide links to other internet sites for the convenience of users. FeyeCon is not responsible for the availability or content of these external sites, nor does FeyeCon endorse, warrant, or guarantee the products, services, or information described or offered at these other internet sites.</p>
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<p><strong>Privacy</strong></p>
<p><em>Personal information </em>FeyeCon does not require personal information from their visitors, nor does FeyeCon collect any personally identifying information (name, e-mail address, Social Security number, or other unique identifier) unless you knowingly provide it. Likewise, we do not give, sell, or transfer any personal information to a third party except as might be required by law. <em>Data collection for statistics </em>To aid in web site management, certain information is collected for statistical purposes. The Service uses specialized software to create summary statistics, which are used for such purposes as assessing what information is of most and least interest to our customers, determining technical design specifications, and identifying system performance or problem areas. We collect only the following information about your visit: 1) The name of the domain from which you access the Internet (for example, tudelft.nl). 2) The web site from which you linked directly to our web site. 3) The operating system and web browser you use to view pages. 4) The date and time you access our web site. We use the information we collect to measure the number of visitors to the different sections of our web site, allowing us to make our web site more useful and accessible to visitors. We do not store any personal identifiers.</p>
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<p><strong>Copyright notice</strong></p>
<p>All rights, including copyright, in the content of these web pages, including downloads, are owned or controlled for these purposes by FeyeCon. In accessing FeyeCon's web pages, you agree that you may only download the content for your own personal non-commercial use. You are not permitted to copy, broadcast, download, store (in any medium), transmit, show or play in public, adapt or change in any way the content of the FeyeCon web pages for any other purpose whatsoever without the prior written permission of FeyeCon.</p>
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<p><strong>Credits</strong></p>
<p>Graphic concept: <font face="Helvetica, Verdana, Arial"><font color="#0000FF"><u><a href="http://www.combustic.nl">Combustic</a></u></font></font>.<br />
Graphic design and production: <font face="Helvetica, Verdana, Arial"><font color="#0000FF"><u><a href="http://www.beelders.nl">Beelders</a></u></font></font>.</p>
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<p><strong>Keywords, search strings</strong></p>
<p>super critical co2, supercritical, hubert pellikaan, drug delivery, inhalation, nanonisation, nanoparticles, encapsulation, particle engineering, particle design, co-precipitation, liposomes, pulmonal vaccination, pulmonal insulin, peptide formulation, formulation, frank wubbolts, pgss, compressed gas, processing, encapsulation, taste masking, ress, pca, gas, sas, ases, seds, precipitation, gerard hofland, vegetable, drying, encapsulation, powder, food, nutraceutical, nanocomposite, foam, glass transition temperature, transparent, co2, geert woerlee, food, pharma, pressure, textile processing, textile dyeing, cotton, polyester, silk, leather, wool, polymer impregnation, solubility measurements, view cell, phase behavior, martijn van der kraan, foam, polymer foam, microcellular foam, ps foam, pe foam, pp foam, pei foam, nanofoam, catalyst, catalyst synthesis, catalyst production, heterogeneous catalyst, polymerization, polycondensation, tjerk de vries, dry-cleaning, surfactant, detergent, clothing, textile, maaike van roosmalen, emulsion drying, depyrogenisation, cannabinoid, alginate, d9-thc, thc, cbd, tetrahydrocannabinol, cannabidiol, bas vermeulen, super critical co2, extraction, high pressure equipment, separation, ernst siewers, thermodynamics, phase equilibria, food applications, agro-bio materials, solvent replacement strategies, peter jan smits pj, vanesa fernandez, arjen de ruiter, farmalyse, johan bender, daan crommelin, erik frijlink, gerrit borchard, michael wiggenhorn, gerhard winter, lmu munchen, yohana perez, annet butter duits, peter jansens, geert jan witkamp, gerda van rosmalen, bas vermeulen, concha domingo, peng robinson, van der waals, peter york, michel perrut, boris shekunov, keith johnston, subramaniam</p>
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