Solutions
FORMULATION
Using our innovative CO2 platform technology, FeyeCon offers various formulation solutions. Supercritical fluid technology is very attractive for manufacturing therapeutic particles, either the API itself, possible excipients or a mixture of both. Optimized drug formulation and delivery improve the therapeutic profile of the final drug. Examples of our solutions include:
- Increased bioavailability
- Controlled release
- Alternative routes of administration
- Taste masking
- Extended stability & shelf life
- Mild processing
- Extraction of organic solvents
- Free flowing particulates
Formulation issues might hamper the therapeutic possibilities of API’s and their commercial success. Several traditional approaches have been developed to create nano-particles, with different degrees of success. Using carbon dioxide as an alternative for organic solvents provides for a greener processing, while the technique allows for mild processes for micronisation and microencapsulation. Managing the particle production process, will also allow for morphology control. 
Release profiles of any compound can be tailored through control of particle size and morphology, which has an effect on solubility. Mild processes for micronisation and microencapsulation allow for an easy, yet effective formulation of particles.
Further adjustments on the solubility and release profile can be achieved through formation of co-crystals or solid solutions. The selection of the appropriate strategy (or a combination thereof) depends on the nature of the active compound and administration route.
The design of your drug formulation might require you to look into alternative routes of administration. Oral administration of peptides, pulmonal administration of degradable actives, or drug loaded gels is achievable with the use of our technology. Selection of the formulation can allow for exploiting the benefits of other routes. FeyeCon has successfully shown to be able to create alternative drug formulations for oral, sublingual, pulmonary or nasal administration.
Taste, smell and after taste are important factors in the development of any drug. These are important product characteristics effecting product preference and therapy loyalty by the patient. FeyeCon can meet your specific taste masking requirements by micro-encapsulating the drug particles.
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In order to create more stability and extend the shelf life of your formulation, a number of possibilities are offered, such as CO2 mild drying or gentle microencapsulation techniques. Mild drying techniques result in successful stabilization of sensitive APIs with the retention of structural integrity and bioavailability. Gentle micro-encapsulation via supercritical CO2 processing is particularly advantageous for materials that are sensitive to temperature, oxidation and light.
The use of our technology will allow for production processes with less organic solvents, risk of heat damage to the active or oxidation. At the same time, the use of high pressure CO2 allows for a reduction of the carbon footprint of your production process. Mild processing can be achieved through:
Lowering the level of organic solvents in ingredients can be done by using our technology. Organic solvent usually dissolve easily in the high pressure CO2. FeyeCon is able to customize this process to your needs.
Our drying technique allows particle formation and drying in a single step. Multiple of excipients can be used, to create a free flowing powder. Bioactivity and molecular integrity have been shown to be preserved. This technique offers possibilities to optimize your production process.
Contact FeyeCon to discover your solution!
